启动子产品信息
订购信息
货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
PR10364 |
Mouse |
pcDNA3.1-EGFP |
|
询价
|
3-4 周 |
产品参数
Gene Promoter: Tyrosinase Related Protein
Specificity: Melanocytes & melanoma
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-TRP1(mouse) Map 产品说明书(点击下载)
产品说明
Description:
The TRP1 gene encodes the tyrosinase-related protein 1, an enzyme involved in the process that converts tyrosinase to melanin pigments. Expression of TRP1 is restricted to melanocytes and melanoma cells partly as a consequence of transcriptional regulation of its mRNA. The TRP1 promoter shares with the tyrosinase promoter an 11-bp motif termed the M box located upstream of the TATA box. This M box plays a key role in the regulation of the TRP1 expression by cyclic AMP (cAMP) [1]. Tissue-specific expression of transgenes, such as the IL-2 and HSV1-tk genes, driven by the TRP1 promoter has been demonstrated in murine model systems, achieving marked antitumor effects [2].
1. Bertolotto C. et al. 1996. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia Mol Cell Biol. 18(2):694-702.
2. Hart IR. 1996. Tissue specific promoters in targeting systemically delivered gene therapy. Semin Oncol. 23(1):154-8.
立即购买
加入购物车