启动子产品信息
订购信息
货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
PR10342 |
Human |
pcDNA3.1-EGFP |
|
询价
|
3-4 周 |
产品参数
Gene Promoter: L-Plastin (Lymphocyte cytosolic protein 1)
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-LP(human) Map 产品说明书(点击下载)
产品说明
Description:
L-plastin (LP) belongs to a family of genes which encode actin-binding proteins. LP is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells. A 315-bp fragment of the 5’ region of the L-plastin gene, spanning the TATAAA box and a potential Sp1-binding site, is sufficient to exhibit strong promoter activity [1]. The L-plastin promoter driving the expression of a suicide gene was used to successfully inhibit the growth of ovarian tumor cells in vitro and in vivo [2].
1. Lin CS. et al. 1993. Characterization of the human L-plastin gene promoter in normal and neoplastic cells. J Biol Chem 268(4):2793-801.
2. Peng XY et al. 2001. The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Cancer Res 61(11):4405-13.
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