启动子产品信息
订购信息
| 货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
| PR10325 |
Human |
pDRIVE5-SEAP |
|
询价
|
3-4 周 |
产品参数
Gene Promoter: E2F1 Transcription factor 1
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-E2F-1(human) Map 产品说明书(点击下载)
pDRIVE5-SEAP-E2F-1(human) Map 产品说明书(点击下载)
pDRIVE5-SEAP-E2F-1(human) Sequence 产品说明书(点击下载)
产品说明
Description:
E2F transcription factors are critical regulators of cell growth and are often overexpressed in cancer cells because of the frequent aberrations in the pRb/E2F/p16(INK4a) pathway. E2F-1 is a transcription factor that activates its own transcription and that of other genes involved in the G(1) to S transition phase of the cell cycle. The E2F-1 promoter was used in an adenovirus to drive the expression of the E1A adenoviral gene and induced selective killing in a variety of tumor cell lines [1].
1. Tsukuda K. et al. 2002. An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 62(12):3438-47.
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