启动子产品信息
订购信息
| 货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
| PR10322 |
Human |
pcDNA3.1-EGFP |
|
询价
|
3-4 周 |
产品参数
Gene Promoter: CXC-Chemokine receptor 4
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-CXCR4(human) Map 产品说明书(点击下载)
产品说明
Description:
CXCR4 is the receptor for the chemokine SDF1 and a coreceptor for HIV-1 entry. The expression of CXCR4 is upregulated in many types of cancers but low in the liver and other major organs. The CXCR4 promoter contains a TATAbox, a nuclear respiratory factor-1 (NRF-1) site, and for GC boxes [1].
A 279 bp fragment of the CXCR4 promoter was shown to have a “tumor-on” status in vitro and in vivo particularly in melanoma and breast cancers [2].
1. Moriuchi M. et al., 1997. Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. J Immunol. 159(9):4322-9.
2. Zhu ZB. et al., 2004. Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter. Gene Ther. 11(7):645-8.
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