启动子产品信息
订购信息
货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
PR10259 |
Rattus |
pDrive |
|
询价
|
3-4 周 |
产品参数
Gene Promoter: NSE : Neuron-Specific Enolase
Specificity: Mature neurons
Backbone: pDRIVE, pDRIVE5-SEAP, ect.
产品说明书
pDRIVE-NSE / RU5'(rat) Map 产品说明书(点击下载)
pDRIVE5-SEAP-NSE / RU5'(rat) Map 产品说明书(点击下载)
pDRIVE5-SEAP-NSE / RU5'(rat) Sequence 产品说明书(点击下载)
产品说明
Description:
Neuron-specific enolase, an isoenzyme form of enolase, occurs in mature neurons and paraneurons. Transgenic mouse studies have shown that a 1.8 kb fragment of the rat NSE promoter is able to express a heterologous gene exclusively in postmitotic neurons and neuro-endocrine cells in parallel with endogenous NSE [1]. The NSE promoter contains a TATA-like sequence, no CAAT box and sequences for the AP-1 binding motif, AP-2 binding element, SP-1 binding sequence and cAMP response element [2]. The NSE promoter was used to create transgenic mice exhibiting the neuropathological phenotypes of Alzheimer's disease [3].
1. Forss-Petter S. et al. 1990. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 5(2):187-97.
2. Sakimura K. et al. 1995. Upstream and intron regulatory regions for expression of the rat neuron-specific enolase gene. Brain Res Mol B 28(1):19-28.
3. Hwang DY. et al., 2004. Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw. Exp Neurol. 186(1):20-32.
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