启动子产品信息
订购信息
货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
PR10243 |
Mouse |
pUC57 |
|
询价
|
2-3 周 |
产品参数
Gene Promoter: Interferon Beta
Specificity: Hematopoietic cells
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-INF-β(mouse) Map 产品说明书(点击下载)
产品说明
Description:
Expression of the interferon-beta (IFN-β) gene is induced by a variety of agents, including viruses and double-stranded RNA (dsRNA), and is also strongly repressed in uninduced cells, a requirement imposed by the cytotoxic properties of IFN-β. The functional IFN-β promoter resides within a 170 bp fragment located 5’ of the coding sequence [1]. This region contains four binding sites for transcription factors such as NF-κB and IRF-1 that act as activators, as well as putative negative regulatory domains. Fusion of the IFN-β promoter region to the luciferase gene was shown to render the expression of the reporter gene inducible by dsRNA [2].
1. Dirks W. et al., 1989. Isolation and functional characterization of the murine interferon-beta 1 promoter. J Interferon Res. 9(1):125-33.
2. King P& Goodbourn S. 1994. The betainterferon promoter responds to priming through multiple independent regulatory elements. J Biol Chem. 269(48):30609-15.
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