启动子产品信息
订购信息
| 货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
| PR10198 |
Mouse |
pUC57 |
|
询价
|
2-3 周 |
产品参数
Gene Promoter: Homolog of Macrosialin
Specificity: Macrophages
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-CD68(human&mouse) Map 产品说明书(点击下载)
pDRIVE5-SEAP-CD68(mouse) Map 产品说明书(点击下载)
pDRIVE5-SEAP-CD68(mouse) Sequence 产品说明书(点击下载)
产品说明
Description:
Murine macrosialin and its human homolog CD68 are heavily glycosylated transmembrane proteins expressed specifically in macrophages and macrophage-related cells. The CD68 gene promoter directs macrophage-specific expression. Although the promoter lacks a classical TATA box, it contains other protein binding sites consistent with preferential monocyte/macrophage gene expression1. CD68 promoter has been used to achieve constitutive expression of IL-10 specifically in macrophages [2].
1. Jiang Z. et al. 1998. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics 50(2):199-205.
2. Lang R.et al. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol. 168(7):3402-11.
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