启动子产品信息
订购信息
货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
PR10164 |
Human |
pDrive |
|
询价
|
3-4 周 |
产品参数
Gene Promoter: Alb: Albumin
Specificity: Liver
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-SV40 / hAlb(human) Map 产品说明书(点击下载)
pDRIVE-SV40 / hAlb(human) Sequence 产品说明书(点击下载)
pDRIVE5-SEAP-SV40 / hAlb(human) Map 产品说明书(点击下载)
产品说明
Description:
The albumin gene is transcribed at very high levels in fetal liver and, unlike the adjacent AFP gene, remains active after birth. A small segment of the bovine albumin 5’flanking region, from -170 to +20, is sufficient for promoter activity and specificity [1]. This segment contains the CCAAT box, TATA box and the binding site of HNF1, a liver specific transcription factor. The albumin promoter is a liver-specific promoter. It can drive the expression of a transgene, such as HSV-tk, specifically in hepatocellular carcinoma cells eliminating the risk of systemic toxicity of GCV [2].
1. Power SC. et al. 1994. Isolation and functional analysis of the promoter of the bovine serum albumin gene. Biochem Biophys Res Com 203(3):1447-1456.
2. Kuriyama S. et al. 1997. Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma. Int J Cancer. 71(3):470-5.
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