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订购信息
| 货号 |
种属 |
载体 |
描述 |
价格 |
周期 |
| PR10157 |
Human |
pGL3-basic |
|
询价
|
5-7 周 |
产品参数
Gene Promoter: Ubiquitin B
Specificity: Ubiquitous
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.
产品说明书
pDRIVE-Ubiquitin B(human) Map 产品说明书(点击下载)
pDRIVE-Ubiquitin B(human) Sequence 产品说明书(点击下载)
pDRIVE5-SEAP-Ubiquitin B(human) Map 产品说明书(点击下载)
pDRIVE5-SEAP-Ubiquitin B(human) Sequence 产品说明书(点击下载)
产品说明
Description:
Ubiquitin B (Ubi B) is a small highly conserved protein that is abundantly expressed in all eukaryotic cells. Ubi B is involved in the degradation of short-lived regulatory proteins as well as abnormal/mutated proteins and in the processing of major histocompatibility class I-restricted antigens [1]. A 1.1 kb fragment from the ubiquitin B gene was shown to display sustained expression of a transgene in vitro and in vivo. Twenty days post-injection, the levels of expression were similar to those obtained with the CMV promoter and were higher 35 days post-injection [2].
1. Ciechanover A. and Schwartz AL. 1998. The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci USA 95(6):2727-30.
2. Yew NS. et al. 2001. High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter. Mol Ther. 4(1):75-82.
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